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Structural basis of HIV-1 Vif-mediated E3 ligase targeting of host APOBEC3H

28 Aug 2023

Abstract excerpt

Human APOBEC3 (A3) cytidine deaminases are antiviral factors that are particularly potent against retroviruses. As a countermeasure, HIV-1 uses a viral infectivity factor (Vif) to target specific human A3s for proteasomal degradation. Vif recruits cellular transcription cofactor CBF-β and Cullin-5 (CUL5) RING E3 ubiquitin ligase to bind different A3s distinctively, but how this is accomplished remains unclear in...

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PMID: 37640699
DOI: 10.1038/s41467-023-40955-x

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