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Article

Various strategies for developing APOBEC3G protectors to circumvent human immunodeficiency virus type 1.

European journal of medicinal chemistry - 15 Mar 2023

Bao Qiqi, Zhou Jinming

Abstract excerpt

Host restriction factor APOBEC3G (A3G) efficiently restricts Vif-deficient HIV-1 by being packaged with progeny virions and causing the G to A mutation during HIV-1 viral DNA synthesis as the progeny virus infects new cells. HIV-1 expresses Vif protein to resist the activity of A3G by mediating A3G degradation. This process requires the self-association of Vif in concert with A3G proteins, protein chaperones, and...

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Identifiers

PMID: 36773550
DOI: 10.1016/j.ejmech.2023.115188

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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