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Article

Abnormal nucleoli architecture and aggregate formation in nucleophosmin mutated acute myeloid leukaemia.

Journal of cell science - 15 May 2025

Grundy Martin, Lucken Kellie, Xing Xiaomeng, Simpson Eva L, Worker Alice, Bayyoomi Ahmed, Beckett Alison J, Prior Ian A, Booth Daniel G, Seedhouse Claire H

Abstract excerpt

Mutations in the nucleophosmin (NPM1) gene represent the most common genetic alteration in acute myeloid leukaemia (AML) and result in mis-localisation of the mutated protein from a predominantly nucleolar localisation to a predominantly cytoplasmic distribution. Here, we use high resolution imaging to demonstrate that NPM1 is crucial for maintaining normal nucleoli architecture and specifically the integrity of...

Read the complete abstract on PubMed

Topics

Nucleophosmin
Humans
Leukemia, Myeloid, Acute
Cell Nucleolus
Nuclear Proteins
Mutation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Cell Line, Tumor

RNA Polymerase I

Chromatin

Source

Open in PubMed Open full text

Identifiers

PMID: 40260502
DOI: 10.1242/jcs.263553
PMCID: PMC12148033

Genes

NPM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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