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Article

ACE2-expressing endothelial cells in aging mouse brain

2020-07-11

Abstract excerpt

Angiotensin-converting enzyme 2 (ACE2) is a key receptor mediating the entry of SARS-CoV-2 into the host cell. Through a systematic analysis of publicly available mouse brain sc/snRNA-seq data, we found that ACE2 is specifically expressed in small sub-populations of endothelial cells and mural cells, namely pericytes and vascular smooth muscle cells. Further, functional changes in viral mRNA transcription and repl...

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Identifiers and source

Literature Corpus work
6455abea-b20a-58cc-a6b3-12d36dc4a437
DOI
10.1101/2020.07.11.198770
Open publication

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ACE2-expressing endothelial cells in aging mouse brainDOI 10.1101/2020.07.11.198770
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