Article
Genome-wide reversal of glial and neurovascular cell transcriptomic aging signatures by GLP-1R agonism
2020-12-22
Abstract excerpt
Pharmacological reversal of brain aging is a long-sought yet challenging strategy for the prevention and treatment of age-related neurodegeneration, due to the diverse cell types and complex cellular pathways impacted by the aging process. Here, we report the genome-wide reversal of transcriptomic aging signatures in multiple major brain cell types, including glial and mural cells, by glucagon-like peptide-1 recep...
Topics
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- Alzheimer's disease research and treatments
- Barrier Structure and Function Studies
- Biochemical effects in animals
- Cholesterol and Lipid Metabolism
- Genetics, Aging, and Longevity in Model Organisms
- Neurogenesis and neuroplasticity mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- RNA regulation and disease
Identifiers and source
- Literature Corpus work
- 6878bbd5-add4-5600-be01-d7f7fc16da82
- DOI
- 10.1101/2020.12.21.423879