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Article

A network of immune and microbial modifications underlies viral persistence in the gastrointestinal tract.

The Journal of experimental medicine - 7 Dec 2020

Macleod Bethany L, Elsaesser Heidi J, Snell Laura M, Dickson Russell J, Guo Mengdi, Hezaveh Kebria, Xu Wenxi, Kothari Akash, McGaha Tracy L, Guidos Cynthia J, Brooks David G

Abstract excerpt

Many pathogens subvert intestinal immunity to persist within the gastrointestinal tract (GIT); yet, the underlying mechanisms that enable sanctuary specifically in this reservoir are unclear. Using mass cytometry and network analysis, we demonstrate that chronic LCMV infection of the GIT leads to dysregulated microbial composition, a cascade of metabolic alterations, increased susceptibility to GI disease, and a...

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Identifiers

PMID: 32880629
DOI: 10.1084/jem.20191473
PMCID: PMC7953734

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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