Article

Cirrhosis-associated immune dysfunction reflects impaired intestinal CD8αβ⁺ intraepithelial lymphocyte compartmentalization

2026-03-30

Abstract excerpt

<h4>Summary</h4> Bacterial infections are major drivers of decompensation and mortality in cirrhosis, yet the mechanisms underlying cirrhosis-associated immune dysfunction remain incompletely understood. Although current models frequently invoke adaptive immune exhaustion, intestinal intraepithelial lymphocytes (IELs), a central barrier immune compartment responsible for epithelial surveillance and microbial cont...

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Literature Corpus work: f4792622-c1df-59f0-b96d-79892a86623b
DOI: 10.64898/2026.03.26.713594

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