Article

A homeostatic interferon-lambda response to bacterial microbiota stimulates preemptive antiviral defense within discrete pockets of intestinal epithelium

2021-06-02

Abstract excerpt

Interferon-lambda (IFN-λ) protects intestinal epithelial cells (IECs) from enteric viruses by inducing expression of antiviral IFN-stimulated genes (ISGs). Here, we find that bacterial microbiota stimulate a homeostatic ISG signature in the intestine of specific pathogen-free mice. This homeostatic ISG expression is restricted to IECs, depends on IEC-intrinsic expression of IFN-λ receptor ( Ifnlr1 ), and is assoc...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: cb316687-ab19-5c85-aef4-de3429acae01
DOI: 10.1101/2021.06.02.446828

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A homeostatic interferon-lambda response to bacterial microbiota stimulates preemptive antiviral defense within discrete pockets of intestinal epitheliumDOI 10.1101/2021.06.02.446828Read

Homeostatic interferon-lambda response to bacterial microbiota stimulates preemptive antiviral defense within discrete pockets of intestinal epitheliumSemantic proximity Read

Plasmacytoid dendritic cells in the intestine preferentially produce interferon lambda at homeostasis contributing to tonic localized innate immune responsesSemantic proximity Read

Interferon-Lambda: A Potent Regulator of Intestinal Viral InfectionsSemantic proximity Read

Type I interferon signalling in the intestinal epithelium affects Paneth cells, microbial ecology and epithelial regeneration.Semantic proximity Read

Analysis of intestinal epithelial cell responses to Cryptosporidium highlights the temporal effects of IFN-γ on parasite restrictionSemantic proximity Read

Type I interferon signaling promotes mucosal inflammation in murine models of colitisSemantic proximity Read

Human enteric viruses autonomously shape inflammatory bowel disease phenotype through divergent innate immunomodulation.Semantic proximity Read

Intestinal antiviral signaling is controlled by autophagy gene Epg5 independent of the microbiotaSemantic proximity Read

Human enteric viruses shape disease phenotype through divergent innate immunomodulationSemantic proximity Read

Enteric viruses evoke broad host immune responses resembling those elicited by the bacterial microbiomeSemantic proximity Read

A transmissible γδ intraepithelial lymphocyte hyperproliferative phenotype is associated with the intestinal microbiota and confers protection against acute infection.Semantic proximity Read

Double-Stranded RNA of Intestinal Commensal but Not Pathogenic Bacteria Triggers Production of Protective Interferon-βSemantic proximity Read