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Intestinal tuft cell immune privilege enables norovirus persistence

22 Mar 2024

Abstract excerpt

The persistent murine norovirus strain MNV CR6 is a model for human norovirus and enteric viral persistence. MNV CR6 causes chronic infection by directly infecting intestinal tuft cells, rare chemosensory epithelial cells. Although MNV CR6 induces functional MNV-specific CD8 + T cells, these lymphocytes fail to clear infection. To examine how tuft cells promote immune escape, we interrogated tuft cell...

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PMID: 38517952
DOI: 10.1126/sciimmunol.adi7038

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