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Article

Tissue environment, not ontogeny, defines murine intestinal intraepithelial T lymphocytes.

eLife - 2 Sept 2021

Brenes Alejandro J, Vandereyken Maud, James Olivia J, Watt Harriet, Hukelmann Jens, Spinelli Laura, Dikovskaya Dina, Lamond Angus I, Swamy Mahima

Abstract excerpt

Tissue-resident intestinal intraepithelial T lymphocytes (T-IEL) patrol the gut and have important roles in regulating intestinal homeostasis. T-IEL include both induced T-IEL, derived from systemic antigen-experienced lymphocytes, and natural T-IEL, which are developmentally targeted to the intestine. While the processes driving T-IEL development have been elucidated, the precise roles of the different subsets...

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Identifiers

PMID: 34473623
DOI: 10.7554/eLife.70055
PMCID: PMC8463072

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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