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Article

Divergent FUS phosphorylation in primate and mouse cells following double-strand DNA damage.

Neurobiology of disease - 1 Dec 2020

Johnson Michelle A, Deng Qiudong, Taylor Georgia, McEachin Zachary T, Chan Anthony W S, Root Jessica, Bassell Gary J, Kukar Thomas

Abstract excerpt

Fused in sarcoma (FUS) is a RNA/DNA protein involved in multiple nuclear and cytoplasmic functions including transcription, splicing, mRNA trafficking, and stress granule formation. To accomplish these many functions, FUS must shuttle between cellular compartments in a highly regulated manner. When shuttling is disrupted, FUS abnormally accumulates into cytoplasmic inclusions that can be toxic. Disrupted...

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Identifiers

PMID: 32950644
DOI: 10.1016/j.nbd.2020.105085
PMCID: PMC8064403

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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