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Childhood acute lymphoblastic leukemia mercaptopurine intolerance is associated with NUDT15 variants.

Pediatric research - 1 Jan 2021

Wang Der-Shiun, Yu Chih-Hsiang, Lin Chien-Yu, Chang Ya-Hsuan, Lin Kai-Hsin, Lin Dong-Tsamn, Jou Shiann-Tarng, Lu Meng-Yao, Chang Hsiu-Hao, Lin Shu-Wha, Chen Hsuan-Yu, Yang Yung-Li

Abstract excerpt

BACKGROUND: Mercaptopurine-induced neutropenia can interrupt chemotherapy and expose patients to infection during childhood acute lymphoblastic leukemia (ALL) treatment. Previously, six candidate gene variants associated with mercaptopurine intolerance were reported. Herein, we investigated the association between the mean tolerable dose of mercaptopurine and these genetic variants in Taiwanese patients. METHODS:...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32221476
DOI: 10.1038/s41390-020-0868-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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