Article
Severe Thiopurine-Induced Myelosuppression in a Pediatric Acute Lymphoblastic Leukemia Patient With the NUDT15 *1/*6 Genotype: A Brief Report.
Clinical and translational science - 1 Jun 2026
Fry Jillian, Boone Erin C, Wang Wendy Y, John Shobana, Lansdon Lisa A, Farooqi Midhat S, Yoo Byunggil, Gaedigk Andrea, August Keith, Flatt Terrie G, Ramsey Laura B
Abstract excerpt
Variants in TPMT and NUDT15 genes that affect thiopurine metabolism can guide personalized dosing to minimize toxicity. Decreased or no appreciable NUDT15 activity demonstrates impaired breakdown of active thiopurine metabolites which can lead to severe adverse events including potentially life-threatening myelosuppression. Recently, the NUDT15*6 allele was re-classified from having uncertain function to no...
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