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The R614E mutation of mouse Mx1 protein contributes to the novel antiviral activity against classical swine fever virus.

Veterinary microbiology - 1 Apr 2020

Chen Jing, Wu Yue, Wu Xu-Dan, Zhou Jing, Liang Xiao-Dong, Baloch Abdul Sattar, Qiu Ya-Feng, Gao Song, Zhou Bin

Abstract excerpt

Mx proteins are interferon-induced GTPases that have broad antiviral activity against a wide range of RNA and DNA viruses. We previously demonstrated that porcine Mx1 protein (poMx1) inhibited the replication of classical swine fever virus (CSFV), an economically important Pestivirus, and that mouse Mx1 did so as well. It is unknown why the nucleus-localizing mouse Mx1 inhibits CSFV replication which occurs in...

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PMID: 32273007
DOI: 10.1016/j.vetmic.2020.108621

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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