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Article

Nuclear localization of mouse Mx1 protein is necessary for inhibition of influenza virus

1 Aug 1992

Abstract excerpt

The interferon-induced Mx1 protein of mice confers selective resistance to influenza virus. It inhibits viral mRNA synthesis in the nucleus of influenza virus-infected cells. The related human MxA protein is localized in the cytoplasm and can inhibit influenza virus and vesicular stomatitis virus but not other viruses. MxA blocks a poorly defined cytoplasmic multiplication step of influenza virus that follows...

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PMID: 1321288
DOI: 10.1128/jvi.66.8.5059-5066.1992

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