Article
Disease causing mutants of TDP-43 nucleic acid binding domains are resistant to aggregation and have increased stability and half-life.
Proceedings of the National Academy of Sciences of the United States of America - 18 Mar 2014
Austin James A, Wright Gareth S A, Watanabe Seiji, Grossmann J Günter, Antonyuk Svetlana V, Yamanaka Koji, Hasnain S Samar
Abstract excerpt
Over the last two decades many secrets of the age-related human neural proteinopathies have been revealed. A common feature of these diseases is abnormal, and possibly pathogenic, aggregation of specific proteins in the effected tissue often resulting from inherent or decreased structural stability. An archetype example of this is superoxide dismutase-1, the first genetic factor to be linked with amyotrophic...
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