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The dual functions of the extreme N-terminus of TDP-43 in regulating its biological activity and inclusion formation

10 Apr 2013

Abstract excerpt

TAR DNA-binding protein-43 (TDP-43) is the principal component of ubiquitinated inclusions in amyotrophic lateral sclerosis (ALS) and the most common pathological subtype of frontotemporal dementia-frontotemporal lobar degeneration with TDP-43-positive inclusions (FTLD-TDP). To date, the C-terminus of TDP-43, which is aggregation-prone and contains almost all ALS-associated mutations, has garnered much attention...

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PMID: 23575225
DOI: 10.1093/hmg/ddt166

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