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Article

The N-terminal dimerization is required for TDP-43 splicing activity.

Scientific reports - 21 Jul 2017

Jiang Lei-Lei, Xue Wei, Hong Jun-Ye, Zhang Jun-Ting, Li Min-Jun, Yu Shao-Ning, He Jian-Hua, Hu Hong-Yu

Abstract excerpt

TDP-43 is a nuclear factor that functions in promoting pre-mRNA splicing. Deletion of the N-terminal domain (NTD) and nuclear localization signal (NLS) (i.e., TDP-35) results in mislocalization to cytoplasm and formation of inclusions. However, how the NTD functions in TDP-43 activity and proteinopathy remains largely unknown. Here, we studied the structure and function of the NTD in inclusion formation and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28733604
DOI: 10.1038/s41598-017-06263-3
PMCID: PMC5522446

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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