Article
Live Imaging of Monocyte Subsets in Immune Complex-Mediated Glomerulonephritis Reveals Distinct Phenotypes and Effector Functions.
Journal of the American Society of Nephrology : JASN - 1 Nov 2020
Turner-Stokes Tabitha, Garcia Diaz Ana, Pinheiro Damilola, Prendecki Maria, McAdoo Stephen P, Roufosse Candice, Cook H Terence, Pusey Charles D, Woollard Kevin J
Abstract excerpt
BACKGROUND: Immune complexes within glomerular capillary walls cause crescentic GN (CrGN). Monocytes and macrophages are important in mediating CrGN, but little work has been done to phenotype the subpopulations involved and determine their respective contributions to glomerular inflammation. METHODS: Live glomerular imaging using confocal microscopy monitored intravascular monocyte subset behavior during...
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