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Article

Nonclassical Ly6C(-) monocytes drive the development of inflammatory arthritis in mice.

Cell reports - 23 Oct 2014

Misharin Alexander V, Cuda Carla M, Saber Rana, Turner Jason D, Gierut Angelica K, Haines G Kenneth, Berdnikovs Sergejs, Filer Andrew, Clark Andrew R, Buckley Christopher D, Mutlu Gökhan M, Budinger G R Scott, Perlman Harris

Abstract excerpt

Different subsets and/or polarized phenotypes of monocytes and macrophages may play distinct roles during the development and resolution of inflammation. Here, we demonstrate in a murine model of rheumatoid arthritis that nonclassical Ly6C(-) monocytes are required for the initiation and progression of sterile joint inflammation. Moreover, nonclassical Ly6C(-) monocytes differentiate into inflammatory macrophages...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25373902
DOI: 10.1016/j.celrep.2014.09.032
PMCID: PMC4223808

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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