Article
Altered immune cell phenotypes within chronically ischemic human kidneys distal to occlusive renal artery disease.
American journal of physiology. Renal physiology - 1 Feb 2024
Zhu Xiang-Yang, Klomjit Nattawat, Pawar Aditya S, Puranik Amrutesh S, Yang Zhi-Zhang, Lutgens Esther, Eirin Alfonso, Lerman Amir, Textor Stephen C, Lerman Lilach O
Abstract excerpt
Renal artery stenosis (RAS) is a major cause of ischemic kidney disease, which is largely mediated by inflammation. Mapping the immune cell composition in ischemic kidneys might provide useful insight into the disease pathogenesis and uncover therapeutic targets. We used mass cytometry (CyTOF) to explore the single-cell composition in a unique data set of human kidneys nephrectomized due to chronic occlusive...
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