Article
Quantification of Macrophage-Driven Inflammation During Myocardial Infarction with 18F-LW223, a Novel TSPO Radiotracer with Binding Independent of the rs6971 Human Polymorphism.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine - 1 Apr 2021
MacAskill Mark G, Stadulyte Agne, Williams Lewis, Morgan Timaeus E F, Sloan Nikki L, Alcaide-Corral Carlos J, Walton Tashfeen, Wimberley Catriona, McKenzie Chris-Anne, Spath Nick, Mungall William, BouHaidar Ralph, Dweck Marc R, Gray Gillian A, Newby David E, Lucatelli Christophe, Sutherland Andrew, Pimlott Sally L, Tavares Adriana A S
Abstract excerpt
Myocardial infarction (MI) is one of the leading causes of death worldwide, and inflammation is central to tissue response and patient outcomes. The 18-kDa translocator protein (TSPO) has been used in PET as an inflammatory biomarker. The aims of this study were to screen novel, fluorinated, TSPO radiotracers for susceptibility to the rs6971 genetic polymorphism using in vitro competition binding assays in human...
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