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Article

The Low-Affinity Binding of Second Generation Radiotracers Targeting TSPO is Associated with a Unique Allosteric Binding Site.

Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology - 1 Mar 2018

Rojas Camilo, Stathis Marigo, Coughlin Jennifer M, Pomper Martin, Slusher Barbara S

Abstract excerpt

[11C]-PK11195 (PK11195) has been widely used with positron emission tomography (PET) to assess levels of the translocator protein 18 kDa (TSPO) as a marker of neuroinflammation. Recent ligands, such as [11C]-PBR28 and [11C]-DPA713, have improved signal-to-noise ratio and specificity for TSPO over PK11195. However, these second generation radiotracers exhibit binding differences due to a single polymorphism...

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Identifiers

PMID: 28875261
DOI: 10.1007/s11481-017-9765-2
PMCID: PMC5790609

Genes

TSPO

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The Low-Affinity Binding of Second Generation Radiotracers Targeting TSPO is Associated with a Unique Allosteric Binding Site.PMID 28875261Read ↗

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