11C-ER176, a Radioligand for 18-kDa Translocator Protein, Has Adequate Sensitivity to Robustly Image All Three Affinity Genotypes in Human Brain.

doi:10.2967/jnumed.116.178996

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Article

11C-ER176, a Radioligand for 18-kDa Translocator Protein, Has Adequate Sensitivity to Robustly Image All Three Affinity Genotypes in Human Brain.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine - 1 Feb 2017

Ikawa Masamichi, Lohith Talakad G, Shrestha Stal, Telu Sanjay, Zoghbi Sami S, Castellano Sabrina, Taliani Sabrina, Da Settimo Federico, Fujita Masahiro, Pike Victor W, Innis Robert B

Abstract excerpt

For PET imaging of 18-kDa translocator protein (TSPO), a biomarker of neuroinflammation, most second-generation radioligands are sensitive to the single nucleotide polymorphism rs6971; however, this is probably not the case for the prototypical agent 11C-PK11195 (11C-labeled N-butan-2-yl-1-(2-chlorophenyl)-N-methylisoquinoline-3-carboxamide), which has a relatively lower signal-to-noise ratio. We recently found...

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PMID: 27856631
DOI: 10.2967/jnumed.116.178996
PMCID: PMC5288742

Genes

TSPO

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