Article
Comprehensive analysis of diverse low-grade neuroepithelial tumors with FGFR1 alterations reveals a distinct molecular signature of rosette-forming glioneuronal tumor.
Acta neuropathologica communications - 28 Aug 2020
Lucas Calixto-Hope G, Gupta Rohit, Doo Pamela, Lee Julieann C, Cadwell Cathryn R, Ramani Biswarathan, Hofmann Jeffrey W, Sloan Emily A, Kleinschmidt-DeMasters Bette K, Lee Han S, Wood Matthew D, Grafe Marjorie, Born Donald, Vogel Hannes, Salamat Shahriar, Puccetti Diane, Scharnhorst David, Samuel David, Cooney Tabitha, Cham Elaine, Jin Lee-Way, Khatib Ziad, Maher Ossama, Chamyan Gabriel, Brathwaite Carole, Bannykh Serguei, Mueller Sabine, Kline Cassie N, Banerjee Anu, Reddy Alyssa, Taylor Jennie W, Clarke Jennifer L, Oberheim Bush Nancy Ann, Butowski Nicholas, Gupta Nalin, Auguste Kurtis I, Sun Peter P, Roland Jarod L, Raffel Corey, Aghi Manish K, Theodosopoulos Philip, Chang Edward, Hervey-Jumper Shawn, Phillips Joanna J, Pekmezci Melike, Bollen Andrew W, Tihan Tarik, Chang Susan, Berger Mitchel S, Perry Arie, Solomon David A
Abstract excerpt
The FGFR1 gene encoding fibroblast growth factor receptor 1 has emerged as a frequently altered oncogene in the pathogenesis of multiple low-grade neuroepithelial tumor (LGNET) subtypes including pilocytic astrocytoma, dysembryoplastic neuroepithelial tumor (DNT), rosette-forming glioneuronal tumor (RGNT), and extraventricular neurocytoma (EVN). These activating FGFR1 alterations in LGNET can include tandem...
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