Histopathological and molecular heterogeneity of dysembryoplastic neuroepithelial tumors.

doi:10.1093/jnen/nlag052

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Article

Histopathological and molecular heterogeneity of dysembryoplastic neuroepithelial tumors.

Journal of neuropathology and experimental neurology - 1 Sept 2026

Wang Yuxiu, Belakhoua Sarra, Yang Yiying, Serrano Jonathan, Horbinski Craig, Boué Daniel R, DeWitt John C, Liechty Benjamin, McGuone Declan, Mao Qinwen, Krasnozhen-Ratush Olga, Yip Stephen, Dunham Christopher, Umphlett Melissa, Shroff Seema, Snuderl Matija

Abstract excerpt

Dysembryoplastic neuroepithelial tumors (DNTs) are low-grade glioneuronal tumors with FGFR1 alterations. They show significant histologic and molecular overlap with other glioneuronal tumors, complicating diagnosis. We analyzed 44 tumors that were either classified as DNT by DNA methylation (n = 37), or were diagnosed histologically as DNT but did not classify as DNT by DNA methylation (n = 7). 13/37 (35%)...

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Topics

Humans
Brain Neoplasms
Neoplasms, Neuroepithelial
Female
DNA Methylation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Male

Receptor, Fibroblast Growth Factor, Type 1

Child

Child, Preschool

Adolescent

Mutation

Infant

Proto-Oncogene Proteins B-raf

Adult

Receptor, Platelet-Derived Growth Factor alpha

Young Adult

Ganglioglioma

Source

Open in PubMed

Identifiers

PMID: 42215018
DOI: 10.1093/jnen/nlag052

Genes

PDGFRA
FGFR1
BRAF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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