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Article

Frequent FGFR1 hotspot alterations in driver-unknown low-grade glioma and mixed neuronal-glial tumors.

Journal of cancer research and clinical oncology - 1 Apr 2022

Engelhardt Sophie, Behling Felix, Beschorner Rudi, Eckert Franziska, Kohlhof Patricia, Tatagiba Marcos, Tabatabai Ghazaleh, Schuhmann Martin U, Ebinger Martin, Schittenhelm Jens

Abstract excerpt

PURPOSE: Low-grade gliomas (LGG) and mixed neuronal-glial tumors (MNGT) show frequent MAPK pathway alterations. Oncogenic fibroblast growth factor receptor 1 (FGFR1) tyrosinase kinase domain has been reported in brain tumors of various histologies. We sought to determine the frequency of FGFR1 hotspot mutations N546 and K656 in driver-unknown LGG/MNGT and examined FGFR1 immunohistochemistry as a potential tool to...

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Identifiers

PMID: 35018490
DOI: 10.1007/s00432-021-03906-x
PMCID: PMC8930952

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