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Article

Glioneuronal Tumour With Neurocytic Differentiation (GNTN): a Molecularly Defined Tumour Type Formerly Referred to as Extraventricular Neurocytoma.

Neuropathology and applied neurobiology - 1 Jun 2026

Métais Alice, Edjlali Myriam, Sassi Farah, Chotard Guillaume, Uro-Coste Emmanuelle, Lhermitte Benoit, Appay Romain, Pinto Giuseppe, Thomas Christian, Bertero Luca, Ratliff Miriam, Krieg Sandro M, von Deimling Andreas, Sahm Felix, Varlet Pascale, Sievers Philipp

Abstract excerpt

Tumours historically classified as extraventricular neurocytoma (EVN), initially in comparison with central neurocytoma, are defined by location and morphology; however, emerging molecular data demonstrate that this term is outdated. We report 14 previously unpublished tumours with a robust EVN DNA methylation profile, independent of original histopathologic diagnosis or anatomic location. Integrated molecular...

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Identifiers

PMID: 42163841
DOI: 10.1111/nan.70080

Genes

FGFR1
NF1
NTRK2
OLIG2
PIK3CA
TACC1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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