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Article

Antibody evolution constrains conformational heterogeneity by tailoring protein dynamics.

Proceedings of the National Academy of Sciences of the United States of America - 12 Sept 2006

Zimmermann Jörg, Oakman Erin L, Thorpe Ian F, Shi Xinghua, Abbyad Paul, Brooks Charles L, Boxer Steven G, Romesberg Floyd E

Abstract excerpt

The evolution of proteins with novel function is thought to start from precursor proteins that are conformationally heterogeneous. The corresponding genes may be duplicated and then mutated to select and optimize a specific conformation. However, testing this idea has been difficult because of the challenge of quantifying protein flexibility and conformational heterogeneity as a function of evolution. Here, we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 16954202
DOI: 10.1073/pnas.0603282103
PMCID: PMC1564241

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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