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Observation of redistribution for local conformational dynamics in cross-reactive antibody design.

Journal of biochemistry - 13 Apr 2026

Yasuda Yoshiki, Nagatoishi Satoru, Sasaki Jiei, Matsunaga Ryo, Kuroda Daisuke, Hashiguchi Takao, Tsumoto Kouhei

Abstract excerpt

Antibody engineering is often achieved through laborious mutagenesis and screening. However, the physicochemical basis of cross-reactivity-enhancing mutations remains unclear. We computationally redesigned the severe acute respiratory syndrome coronavirus (SARS-CoV)-1 neutralizing antibody m396 to recognize the SARS-CoV-2 receptor-binding domain (RBD) and characterized its biophysical properties. A...

Topics

SARS-CoV-2
Antibodies, Viral
Humans
Cross Reactions
Antibodies, Neutralizing
Spike Glycoprotein, Coronavirus
Protein Conformation
Mutation
Protein Engineering

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41810982
DOI: 10.1093/jb/mvag018
PMCID: PMC13064648

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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