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Telomerase Reverse Transcriptase (TERT) Regulation in Thyroid Cancer: A Review

31 Jul 2020

Abstract excerpt

Telomerase reverse transcriptase (TERT) is the catalytic subunit of the enzyme telomerase and is essential for telomerase activity. Upregulation of TERT expression and resulting telomerase activity occurs in the large majority of malignancies, including thyroid cancer. This upregulation results in continued cellular proliferation and avoidance of cellular senescence and cell death. In this review we will briefly...

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PMID: 32849278
DOI: 10.3389/fendo.2020.00485

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