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Article

TERT reactivation in thyroid cancer: mechanisms, clinical implications, and therapeutic opportunities.

European thyroid journal - 1 Oct 2026

Nguyen Linh T T, Glover Anthony, Gild Matti, Bullock Martyn

Abstract excerpt

Somatic mutations in the telomerase reverse transcriptase (TERT) promoter are key molecular events in thyroid carcinogenesis and are strongly associated with aggressive clinical behaviour. The c.-124C>T and c.-146C>T hotspot mutations, discovered in 2013, are now recognised as major mechanisms of TERT reactivation and as independent predictors of disease-specific survival, recurrence, and disease refractoriness...

Read the complete abstract on PubMed

Topics

Humans
Telomerase
Thyroid Neoplasms
Mutation
Promoter Regions, Genetic
Proto-Oncogene Proteins B-raf

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 42715115
DOI: 10.1530/ETJ-26-0068

Genes

TERT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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