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Article

TERT biology and function in cancer: beyond immortalisation.

Journal of molecular endocrinology - 1 Feb 2017

Pestana Ana, Vinagre João, Sobrinho-Simões Manuel, Soares Paula

Abstract excerpt

Evasion of replicative senescence and proliferation without restriction, sometimes designated as immortalisation, is one of the hallmarks of cancer that may be attained through reactivation of telomerase in somatic cells. In contrast to most normal cells in which there is lack of telomerase activity, upregulation of TERT transcription/activity is detected in 80-90% of malignant tumours. In several types of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 28057768
DOI: 10.1530/JME-16-0195

Genes

TERT
MYC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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