Article

Dual TERT Promoter Mutations in Glioblastoma, IDH-Wildtype: A Case Report with Preclinical Investigations

2026-03-08

Abstract excerpt

<title>Abstract</title> <p> Telomerase reverse transcriptase promoter ( <italic>TERT</italic> p) mutations c.-124C > T (C228T) and c.-146C > T (C250T) are the most frequent single-nucleotide variants promoting telomerase activation in glioblastoma. Here, we describe a rare case of glioblastoma <italic>IDH</italic> -wildtype with dual <italic>TERT</italic> p mutations. Genomic analyses of multiregional tumo...

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Literature Corpus work: 8bd3ce87-e36f-5adf-bb13-9b7214eb4b7b
DOI: 10.21203/rs.3.rs-8931482/v1

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