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Article

Fungal kinases and transcription factors regulating brain infection in Cryptococcus neoformans.

Nature communications - 23 Mar 2020

Lee Kyung-Tae, Hong Joohyeon, Lee Dong-Gi, Lee Minjae, Cha Suyeon, Lim Yu-Gyeong, Jung Kwang-Woo, Hwangbo Areum, Lee Yelin, Yu Shang-Jie, Chen Ying-Lien, Lee Jong-Seung, Cheong Eunji, Bahn Yong-Sun

Abstract excerpt

Cryptococcus neoformans causes fatal fungal meningoencephalitis. Here, we study the roles played by fungal kinases and transcription factors (TFs) in blood-brain barrier (BBB) crossing and brain infection in mice. We use a brain infectivity assay to screen signature-tagged mutagenesis (STM)-based libraries of mutants defective in kinases and TFs, generated in the C. neoformans H99 strain. We also monitor in vivo...

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Identifiers

PMID: 32251295
DOI: 10.1038/s41467-020-15329-2
PMCID: PMC7090016

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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