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Article

Sensitivity to monoclonal antibody 447-52D and an open env trimer conformation correlate poorly with inhibition of HIV-1 infectivity by SERINC5.

Virology - 1 Sept 2020

Angerstein Aaron O, Stoneham Charlotte A, Ramirez Peter W, Guatelli John C, Vollbrecht Thomas

Abstract excerpt

The host protein SERINC5 inhibits the infectivity of HIV-1 virions in an Env-dependent manner and is counteracted by Nef. The conformation of the Env trimer reportedly correlates with sensitivity to SERINC5. Here, we tested the hypothesis that the "open" conformation of the Env trimer revealed by sensitivity to the V3-loop specific antibody 447-52D directly correlates with sensitivity to SERINC5. Of five Envs...

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Topics

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Share to Antibodies, Monoclonal
Share to Antibodies, Neutralizing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to env Gene Products, Human Immunodeficiency Virus

Share to HIV Antibodies

Share to HIV Infections

Share to Membrane Proteins

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Source

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Identifiers

PMID: 32838948
DOI: 10.1016/j.virol.2020.06.007
PMCID: PMC7447835

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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