Article
SERINC5 Restricts HIV-1 Infectivity by Promoting Conformational Changes and Accelerating Functional Inactivation of Env.
Viruses - 25 Jun 2022
Kirschman Junghwa, Marin Mariana, Chen Yen-Cheng, Chen Junhua, Herschhorn Alon, Smith Amos B, Melikyan Gregory B
Abstract excerpt
SERINC5 incorporates into HIV-1 particles and inhibits the ability of Env glycoprotein to mediate virus-cell fusion. SERINC5-resistance maps to Env, with primary isolates generally showing greater resistance than laboratory-adapted strains. Here, we examined a relationship between the inhibition of HIV-1 infectivity and the rate of Env inactivation using a panel of SERINC5-resistant and -sensitive HIV-1 Envs....
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