Article

SERINC5 Is the Primary Target of Retroviral Antagonists Among Human SERINC Paralogs and Requires a Tri-Cysteine Motif for Its Counteraction by HIV-1 Nef

2025-10-27

Abstract excerpt

The human transmembrane protein SERINC5 incorporates into budding HIV-1 particles and inhibits their fusion with new target cells. Among the five members of the SERINC family, SERINC3 and SERINC1 exhibit modest antiviral activity, whereas SERINC2 lacks this function. HIV-1 counteracts SERINC5 by promoting its endocytosis in a Nef- dependent manner. SERINC5 is also downregulated by glycoGag of Moloney murine leukae...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d5aebbab-177f-5383-ae94-9b8b516fa2e4
DOI: 10.1101/2025.10.27.684794

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

SERINC5 Is the Primary Target of Retroviral Antagonists Among Human SERINC Paralogs and Requires a Tri-Cysteine Motif for Its Counteraction by HIV-1 NefDOI 10.1101/2025.10.27.684794Read

A Conserved Acidic-Cluster Motif in SERINC5 Confers Partial Resistance to Antagonism by HIV-1 Nef.Semantic proximity Read

SERINC5 as a New Restriction Factor for Human Immunodeficiency Virus and Murine Leukemia VirusSemantic proximity Read

Aromatic Side Chain at Position 412 of SERINC5 Exerts Restriction Activity toward HIV-1 and Other Retroviruses.Semantic proximity Read

Proteasomal degradation of human SERINC4: a potent host anti-HIV-1 factor that is antagonized by NefSemantic proximity Read

SERINC5 Potently Restricts Retrovirus Infection In VivoSemantic proximity Read

Murine Leukemia Virus GlycoGag Antagonizes SERINC5 via ER-phagy Receptor RETREG1Semantic proximity Read

Influence of different glycoproteins and of the virion core on SERINC5 antiviral activitySemantic proximity Read

The retroviral accessory proteins S2, Nef, and glycoMA use similar mechanisms for antagonizing the host restriction factor SERINC5Semantic proximity Read

SERINC5 potently restricts retrovirus infection <i>in vivo</i>Semantic proximity Read

CD4 Expression and Env Conformation Are Critical for HIV-1 Restriction by SERINC5Semantic proximity Read

The Antagonism of HIV-1 Nef to SERINC5 Particle Infectivity Restriction Involves the Counteraction of Virion-Associated Pools of the Restriction Factor.Semantic proximity Read

Variation in HIV-1 Nef function within and among viral subtypes reveals genetically separable antagonism of SERINC3 and SERINC5Semantic proximity Read