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Article

A Conserved Acidic-Cluster Motif in SERINC5 Confers Partial Resistance to Antagonism by HIV-1 Nef.

Journal of virology - 17 Mar 2020

Stoneham Charlotte A, Ramirez Peter W, Singh Rajendra, Suarez Marissa, Debray Andrew, Lim Christopher, Jia Xiaofei, Xiong Yong, Guatelli John

Abstract excerpt

The cellular protein SERINC5 inhibits the infectivity of diverse retroviruses, and its activity is counteracted by the glycosylated Gag (glycoGag) protein of murine leukemia virus (MLV), the S2 protein of equine infectious anemia virus (EIAV), and the Nef protein of human immunodeficiency virus type 1 (HIV-1). Determining the regions within SERINC5 that provide restrictive activity or Nef sensitivity should...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 31941773
DOI: 10.1128/JVI.01554-19
PMCID: PMC7081897

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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A Conserved Acidic-Cluster Motif in SERINC5 Confers Partial Resistance to Antagonism by HIV-1 Nef.PMID 31941773Read ↗

SERINC5 Is the Primary Target of Retroviral Antagonists Among Human SERINC Paralogs and Requires a Tri-Cysteine Motif for Its Counteraction by HIV-1 NefSemantic proximity Read ↗

SERINC5 as a New Restriction Factor for Human Immunodeficiency Virus and Murine Leukemia VirusSemantic proximity Read ↗

The Antagonism of HIV-1 Nef to SERINC5 Particle Infectivity Restriction Involves the Counteraction of Virion-Associated Pools of the Restriction Factor.Semantic proximity Read ↗

Aromatic Side Chain at Position 412 of SERINC5 Exerts Restriction Activity toward HIV-1 and Other Retroviruses.Semantic proximity Read ↗

Potent Enhancement of HIV-1 Replication by Nef in the Absence of SERINC3 and SERINC5Semantic proximity Read ↗

An Amino Acid Polymorphism within the HIV-1 Nef Dileucine Motif Functionally Uncouples Cell Surface CD4 and SERINC5 Downregulation.Semantic proximity Read ↗

Variation in HIV-1 Nef function within and among viral subtypes reveals genetically separable antagonism of SERINC3 and SERINC5Semantic proximity Read ↗

The retroviral accessory proteins S2, Nef, and glycoMA use similar mechanisms for antagonizing the host restriction factor SERINC5Semantic proximity Read ↗

Influence of different glycoproteins and of the virion core on SERINC5 antiviral activitySemantic proximity Read ↗

Murine Leukemia Virus GlycoGag Antagonizes SERINC5 via ER-phagy Receptor RETREG1Semantic proximity Read ↗

CD4 Expression and Env Conformation Are Critical for HIV-1 Restriction by SERINC5Semantic proximity Read ↗

SERINC5 Potently Restricts Retrovirus Infection In VivoSemantic proximity Read ↗

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