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Article

CD4 Expression and Env Conformation Are Critical for HIV-1 Restriction by SERINC5

29 Apr 2019

Abstract excerpt

Restriction factors provide the first line of defense against retrovirus infection by posing several blocks to the viral replication cycle. SERINC5 is a novel restriction factor that strongly blocks HIV-1 entry, although it is counteracted by Nef. Currently, it is still unclear how HIV-1 entry is blocked by SERINC5. Notably, this entry block is dependent on viral Env proteins. Laboratory-adapted HIV-1 strains are...

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PMID: 31043528
DOI: 10.1128/jvi.00544-19

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CD4 Expression and Env Conformation Are Critical for HIV-1 Restriction by SERINC5PMID 31043528Read ↗

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