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Influence of Different Glycoproteins and of the Virion Core on SERINC5 Antiviral Activity

30 Jun 2021

Abstract excerpt

Host plasma membrane protein SERINC5 is incorporated into budding retrovirus particles where it blocks subsequent entry into susceptible target cells. Three structurally unrelated proteins encoded by diverse retroviruses, human immunodeficiency virus type 1 (HIV-1) Nef, equine infectious anemia virus (EIAV) S2, and ecotropic murine leukemia virus (MLV) GlycoGag, disrupt SERINC5 antiviral activity by redirecting...

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PMID: 34209034
DOI: 10.3390/v13071279

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Influence of Different Glycoproteins and of the Virion Core on SERINC5 Antiviral ActivityPMID 34209034Read ↗

Influence of different glycoproteins and of the virion core on SERINC5 antiviral activitySemantic proximity Read ↗

SERINC5 as a New Restriction Factor for Human Immunodeficiency Virus and Murine Leukemia VirusSemantic proximity Read ↗

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SERINC5 Is the Primary Target of Retroviral Antagonists Among Human SERINC Paralogs and Requires a Tri-Cysteine Motif for Its Counteraction by HIV-1 NefSemantic proximity Read ↗

Restriction of Influenza A Virus by SERINC5Semantic proximity Read ↗

A Conserved Acidic-Cluster Motif in SERINC5 Confers Partial Resistance to Antagonism by HIV-1 Nef.Semantic proximity Read ↗

SIVcol Nef counteracts SERINC5 by promoting its proteasomal degradation but does not efficiently enhance HIV-1 replication in human CD4+ T cells and lymphoid tissueSemantic proximity Read ↗

SERINC5 Restricts HIV-1 Infectivity by Promoting Conformational Changes and Accelerating Functional Inactivation of Env.Semantic proximity Read ↗

The retroviral accessory proteins S2, Nef, and glycoMA use similar mechanisms for antagonizing the host restriction factor SERINC5Semantic proximity Read ↗

Aromatic Side Chain at Position 412 of SERINC5 Exerts Restriction Activity toward HIV-1 and Other Retroviruses.Semantic proximity Read ↗

SERINC5 Potently Restricts Retrovirus Infection In VivoSemantic proximity Read ↗

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