Article

Characterization of ACE2 naturally occurring missense variants: impact on subcellular localization and trafficking

2022-02-16

Abstract excerpt

<h4>Background: </h4> Human angiotensin converting enzyme 2 (ACE2), a type I transmembrane receptor physiologically acting as a carboxypeptidase enzyme within the renin-angiotensin system (RAS), is a critical mediator of infection by several severe acute respiratory syndrome (SARS) corona viruses. For instance, it has been demonstrated that ACE2 is the primary receptor for the SARS-CoV-2 entry to many human cells...

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Literature Corpus work: db28eda9-6261-552b-83d2-149bdd337124
DOI: 10.21203/rs.3.rs-1345864/v1

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