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Article

Protein Splicing Activity of the Haloferax volcanii PolB-c Intein Is Sensitive to Homing Endonuclease Domain Mutations.

Biochemistry - 15 Sept 2020

Robinzon Shachar, Cawood Alexandra R, Ruiz Mercedes A, Gophna Uri, Altman-Price Neta, Mills Kenneth V

Abstract excerpt

Inteins are selfish genetic elements residing in open reading frames that can splice post-translationally, resulting in the ligation of an uninterrupted, functional protein. Like other inteins, the DNA polymerase B (PolB) intein of the halophilic archaeon Haloferax volcanii has an active homing endonuclease (HEN) domain, facilitating its horizontal transmission. Previous work has shown that the presence of the...

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Identifiers

PMID: 32822531
DOI: 10.1021/acs.biochem.0c00512
PMCID: PMC7494616

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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