Article
Protein splicing in the absence of an intein penultimate histidine.
The Journal of biological chemistry - 7 Jul 2000
Chen L, Benner J, Perler F B
Abstract excerpt
Protein splicing is a self-catalytic process in which an intervening sequence, termed an intein, is excised from a protein precursor, and the flanking polypeptides are religated. The conserved intein penultimate His facilitates this reaction by assisting in Asn cyclization, which results in C-terminal splice junction cleavage. However, many inteins do not have a penultimate His. Previous splicing studies with 2...
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