Article
Post-translational environmental switch of RadA activity by extein-intein interactions in protein splicing.
Nucleic acids research - 27 Jul 2015
Topilina Natalya I, Novikova Olga, Stanger Matthew, Banavali Nilesh K, Belfort Marlene
Abstract excerpt
Post-translational control based on an environmentally sensitive intervening intein sequence is described. Inteins are invasive genetic elements that self-splice at the protein level from the flanking host protein, the exteins. Here we show in Escherichia coli and in vitro that splicing of the RadA intein located in the ATPase domain of the hyperthermophilic archaeon Pyrococcus horikoshii is strongly regulated by...
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