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Article

Prkar1a haploinsufficiency ameliorates the growth hormone excess phenotype in Aip-deficient mice.

Human molecular genetics - 10 Oct 2020

Schernthaner-Reiter Marie Helene, Trivellin Giampaolo, Roetzer Thomas, Hainfellner Johannes A, Starost Matthew F, Stratakis Constantine A

Abstract excerpt

Mutations of the regulatory subunit (PRKAR1A) of the cyclic adenosine monophosphate (cAMP)-dependent protein kinase (PKA), leading to activation of the PKA pathway, are the genetic cause of Carney complex which is frequently accompanied by somatotroph tumors. Aryl hydrocarbon receptor-interacting protein (AIP) mutations lead to somatotroph tumorigenesis in mice and humans. The mechanisms of AIP-dependent...

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Identifiers

PMID: 32821937
DOI: 10.1093/hmg/ddaa178
PMCID: PMC7566352

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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