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Article

Mild pituitary phenotype in 3- and 12-month-old Aip-deficient male mice.

The Journal of endocrinology - 1 Oct 2016

Lecoq Anne-Lise, Zizzari Philippe, Hage Mirella, Decourtye Lyvianne, Adam Clovis, Viengchareun Say, Veldhuis Johannes D, Geoffroy Valérie, Lombès Marc, Tolle Virginie, Guillou Anne, Karhu Auli, Kappeler Laurent, Chanson Philippe, Kamenický Peter

Abstract excerpt

Germline mutations in the aryl hydrocarbon receptor-interacting protein (AIP) gene predispose humans to pituitary adenomas, particularly of the somatotroph lineage. Mice with global heterozygous inactivation of Aip (Aip(+/-)) also develop pituitary adenomas but differ from AIP-mutated patients by the high penetrance of pituitary disease. The endocrine phenotype of these mice is unknown. The aim of this study was...

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Source

Identifiers

PMID: 27621108
DOI: 10.1530/JOE-16-0190

Genes

AIP
IGF1
GHRH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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