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Article

Interaction of AIP with protein kinase A (cAMP-dependent protein kinase)

2 May 2018

Abstract excerpt

Germline mutations in the aryl hydrocarbon receptor-interacting protein (AIP) gene cause mostly somatotropinomas and/or prolactinomas in a subset of familial isolated pituitary adenomas (FIPA). AIP has been shown to interact with phosphodiesterases (PDEs) and G proteins, suggesting a link to the cyclic AMP (cAMP)-dependent protein kinase (PKA) pathway. Upregulation of PKA is seen in sporadic somatotropinomas that...

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PMID: 29726992
DOI: 10.1093/hmg/ddy166

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