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Article

Interleukin-6 (IL-6) response to a simulated night-shift schedule is modulated by brain-derived neurotrophic factor (BDNF) genotype.

Chronobiology international - 1 Jan 2000

Satterfield Brieann C, Savenkova Marina I, Karatsoreos Ilia N, Jackson Melinda L, Belenky Gregory, Van Dongen Hans P A

Abstract excerpt

The BDNF gene contains a polymorphism (Val66Met) that influences sleep and may be associated with more flexible adaptation to circadian misalignment. Fifteen adult men (10 Val/Val homozygotes, 5 Val/Met heterozygotes) participated in a laboratory study involving two 5 d cycles of simulated night shifts. Circulating interleukin-6 (IL-6) was measured from plasma, sleep was recorded polysomnographically, and...

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PMID: 32819178
DOI: 10.1080/07420528.2020.1803901

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