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Article

The BDNF Val66Met polymorphism modulates sleep intensity: EEG frequency- and state-specificity.

Sleep - 1 Mar 2012

Bachmann Valérie, Klein Carina, Bodenmann Sereina, Schäfer Nikolaus, Berger Wolfgang, Brugger Peter, Landolt Hans-Peter

Abstract excerpt

STUDY OBJECTIVES: EEG slow waves are the hallmark of deep NREM sleep and may reflect the restorative functions of sleep. Evidence suggests that increased sleep slow waves after sleep deprivation reflect plastic synaptic processes, and that brain-derived neurotrophic factor (BDNF) is causally involved in their homeostatic regulation. The functional Val66Met polymorphism of the gene encoding pro-BDNF causes...

Topics

Adult
Arousal
Brain-Derived Neurotrophic Factor
Case-Control Studies
Electroencephalography
Female
Genotype
Humans
Male
Memory
Polymorphism, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Sleep Deprivation

Sleep Stages

Time Factors

Young Adult

Source

Open in PubMed Open full text

Identifiers

PMID: 22379239
DOI: 10.5665/sleep.1690
PMCID: PMC3274334

Genes

BDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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